Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1989-05-15
1991-03-19
Teskin, Robin L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
4351723, 4353201, 4352523, 43525233, 435170, 536 27, 935 14, 935 29, 935 40, 935 60, C12P 706, C07H 1512, C12N 1500
Patent
active
050000004
ABSTRACT:
A novel operon and plasmids comprising genes which code for the alcohol dehydrogenase and pyruvate decarboxylase activities of Zymomonas mobilis are described. Also disclosed are methods for increasing the growth of microorganisms or eukaryotic cells and methods for reducing the accumulation of undesirable metabolic products in the growth medium of microorganisms or cells.
REFERENCES:
Fried, V. A., A. Novick (1973) "Organic Solvents as Probes for the Structure and Function of the Bacterial Membrane: Effects of Ethanol on the Wild Type and an Ethanol-Resistant Mutant of Escherichia coli K-12," J. Bacteriol. 114(1):239-248.
Ingram, L. O. (1976) "Adaptation of Membrane Lipids to Alcohols," J. Bacteriol. 125(2):670-678.
Ingram, L. O., N. S. Vreeland (1980) "Differential Effects of Ethanol and Hexanol on the Escherichia coli Cell Envelope," J. Bacteriol. 144(2):481-488.
Ingram, L. O., T. M. Buttke (1984) "Effects of Alcohols on Micro-Organisms," in Advances in Microbial Pathology, vol. 25, Academic Press, London, pp. 254-295.
Bringer-Meyer, S., K.-L. Schimz, and H. Sahm (1986) "Pyruvate Decarboxylase from Zymomonas mobilis. Isolation and Partial Characterization," Arch. Microbiol. 146:105-110.
Brau, B. and H. Sahm (1986) "Cloning and Expression of the Structural Gene for Pyruvate Decarboxylase of Zymomonas mobilis in Escherichia coli," Arch. Microbiol. 144:296-301.
Conway, T., Y. A. Osman, J. I. Konnan, E. M. Hoffmann, and L. O. Ingram (1987) "Promoter and Nucleotide Sequences of the Zymomonas mobilis Pyruvate Decarboxylase," J. Bacteriol. 169:949-954.
Conway, T., G. W. Sewell, Y. A. Osman and L. O. Ingram (1987) "Cloning and Sequencing of the Alcohol Dehydrogenase II Gene from Zymomonas mobilis," J. Bacteriol. 169:2591-2597.
Neale, A. D., R. K. Scopes, R. E. H. Wettenhall and N. J. Hoogenraad (1987) "Nucleotide Sequence of the Pyruvate Decarboxylase Gene from Zymomonas mobilis," Nucleic Acids Res. 15:1753-1761.
Ingram, L. O. and T. Conway (1988) "Expression of Different Levels of Ethanologenic Enzymes from Zymomonas mobilis in Recombinant Strains of Escherichia coli," Appl. Environ. Microbiol. 54:397-404.
Ingram, L. O., T. Conway, D. P. Clark, G. W. Sewell, and J. F. Preston (1987) "Genetic Engineering of Ethanol Production in Escherichia coli," Appl. Environ. Microbiol. 53:2420-2425.
Tolan, J. S. and R. K. Finn (1987) "Fermentation of D-Xylose and L-Arabinos to Ethanol by Erwinia chrysanthemi," Appl. Environ. Microbiol. 53:2033-2038.
Tolan, J. S. and R. K. Finn (1987) "Fermentation of D-Xylose to Ethanol by Genetically Modified Klebsiella planticola," Appl. Environ. Microbiol. 53:2039-2044.
Alterthum Flavio
Conway Tyrrell
Ingram Lonnie O.
Teskin Robin L.
University of Florida
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