Ethanobicyclic amine derivatives for CNS disorders

Details Ethanobicyclic amine derivatives for CNS disorders Ethanobicyclic amine derivatives for CNS disorders

1991-12-02

1993-06-01

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544380, 544381, A61K 31495, C07D29500

Patent

active

052159922

ABSTRACT:
Certain ethanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of the formula ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and Z is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, phenalkyl, phenyl, alkoxy, phenoxy, phenalkoxy, alkoxyalkyl, halo, haloalkyl and hydroxyalkyl; wherein R.sup.3 and R.sup.4 may be taken together to form oxo;

REFERENCES:
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H. E. Katerinopoulos et al, Eur. J. Med. Chem., 23(4), 391-396 (1988).

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