Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate],...

Details Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate],... Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate],...

2006-03-07

2006-03-07

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C540S521000, C540S522000, C562S496000

Reexamination Certificate

active

07009047

ABSTRACT:
The present invention relates to ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate], the preparation of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylenediamine in 2-propanol, and the use of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] for the preparation of ACE/NEP inhibitors.

REFERENCES:
patent: 0 481 522 (1992-04-01), None
patent: 1 056 715 (2002-06-01), None
patent: WO 99/42438 (1999-08-01), None
Robl Jeffrey A et al., Vasopeptidase Inhibitors: Incorporation Of Geminal And Spirocyclic Substituted Azepinones In Mercaptoacyl Depeptides, Journal Of Medicinal Chemistry, (1999), vol. 42, pp. 305-311.
Robl Jeffrey A et al., Dual Metalloprotease Inhibitors: Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics As Inhibitors Of Angiotensin-Converting Enzyme And Neutral Endopeptidase, Journal Of Medicinal Chemistry, (1997), vol. 40, pp. 1570-1577.

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