Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1980-06-09
1982-07-06
Breitenstein, G. T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424319, 424321, 424322, 424324, 424316, 560 12, 560 13, 560 21, 560 34, 560 42, 562430, 562435, 562439, 562451, 564 51, 564 99, 564162, 564165, A61K 3124, C07C10130
Patent
active
043383335
ABSTRACT:
The compounds of formula (II): ##STR1## in which R.sub.1 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R.sub.2 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl group; R.sub.3 is a hydrogen, chlorine or bromine atom or a hydroxyl group, R.sub.4 is a hydrogen atom or a methyl group; R.sub.5 is a hydrogen atom or a methyl group; R.sub.6 is a hydrogen, fluorine or chlorine atom or a methyl, methoxyl or hydroxy group; X is an oxygen atom or a bond; Y is an alkylene group of up to 6 carbon atoms or a bond; and Z is an alkylene, alkenylene or alkynylene group of up to 10 carbon atoms, have been found to possess anti-obesity and/or anti-hyperglycaemic activity.
REFERENCES:
patent: 4012444 (1977-03-01), Lunts et al.
patent: 4146638 (1979-03-01), Renth et al.
Kamiya et al., Chem. Absts., 84, 164461(m) (1976).
Ainsworth Anthony T.
Smith David G.
Beecham Group Limited
Breitenstein G. T.
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