Ethanamine derivatives their preparation and use in pharmaceutic

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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424319, 424321, 424322, 424324, 424316, 560 12, 560 13, 560 21, 560 34, 560 42, 562430, 562435, 562439, 562451, 564 51, 564 99, 564162, 564165, A61K 3124, C07C10130

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043383335

ABSTRACT:
The compounds of formula (II): ##STR1## in which R.sub.1 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R.sub.2 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl group; R.sub.3 is a hydrogen, chlorine or bromine atom or a hydroxyl group, R.sub.4 is a hydrogen atom or a methyl group; R.sub.5 is a hydrogen atom or a methyl group; R.sub.6 is a hydrogen, fluorine or chlorine atom or a methyl, methoxyl or hydroxy group; X is an oxygen atom or a bond; Y is an alkylene group of up to 6 carbon atoms or a bond; and Z is an alkylene, alkenylene or alkynylene group of up to 10 carbon atoms, have been found to possess anti-obesity and/or anti-hyperglycaemic activity.

REFERENCES:
patent: 4012444 (1977-03-01), Lunts et al.
patent: 4146638 (1979-03-01), Renth et al.
Kamiya et al., Chem. Absts., 84, 164461(m) (1976).

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