Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1996-01-11
1997-07-22
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
564342, 564346, 564347, 540484, 540544, 540553, 544 56, 544582, 544 59, 544 98, 544106, C07C38104, C07C21300
Patent
active
056505418
ABSTRACT:
Compounds structurally related to ethacrynic acid are described. The compounds are useful for controlling intraocular pressure. Unlike ethacrynic acid, the compounds of the present invention are capable of effectively penetrating the cornea. Methods of controlling intraocular pressure via topical application of one or more of the compounds to the eye and topical ophthalmic compositions useful in the treatment of glaucoma are also described.
REFERENCES:
patent: 3255241 (1966-06-01), Schultz et al.
patent: 3352904 (1967-11-01), Bicking et al.
patent: 3419606 (1968-12-01), Bicking et al.
patent: 4324782 (1982-04-01), Cragoe
patent: 4390537 (1983-06-01), Cragoe
patent: 4699926 (1987-10-01), Abraham
patent: 4731381 (1988-03-01), Abraham et al.
patent: 4731473 (1988-03-01), Abraham
patent: 4751244 (1988-06-01), Abraham
patent: 4757089 (1988-07-01), Epstein
patent: 5352702 (1994-10-01), Cyrlin
Davson, H., Physiology of the Eye, 5th Ed., Pergamon Press (1990), pp. 117-122.
Leo, A. J., "Methods of Calculating Partition Coefficients", Comprehensive Medicinal Chemistry: The Rational Design, Mechanistic Study & Therapeutic Applications of Chemical Compounds, vol. 4, #18.7, pp. 295-319, Pergamon Press (1990).
Mirrlees, M. S., et al., "Direct Measurement of Octanol-Water Partition Coefficients by High-Pressure Liquid Chromatography", Journal of Medicinal Chemistry, vol. 19, No. 5, pp. 615-619 (1976).
Wang, W., et al., "Lipophilicity Influence on Conjunctival Drug Penetration in the Pigmented Rabbit: A Comparison with Corneal Penetration", Current Eye Research, vol. 10, No. 6, pp. 571-579 (1991).
Goto, S., et al., "Stability and Serum Albumin Binding of Diuretics in Aqueous Solution", Yakugaku Zasshi, vol. 98, pp. 236-240 (1978).
Abraham, D. J., et al., "Design, Synthesis, and Testing of Potential Antisickling Agents. 7. Ethacrynic Acid Analogues", J. Med. Chem., vol. 32, pp. 2460-2467 (1989).
Epstein, D. L., et al., "N-Ethylmalemide Increases the Facility of Aqueous Outflow of Excised Monkey and Calf Eyes", Invest. Ophthalmol. Vis. Sci., vol. 22, pp. 752-756 (1982).
Epstein, D. L., et al., "Influence of Ethacrynic Acid on Outflow Facility in the Monkey and Calf Eye", Invest. Ophthalmol. Vis. Sci., vol. 28, pp. 2067-2075 (1987).
The Assoc. for Research in Vision and Ophthalmology ARVO 1988, No. 24, p. 84: Ozment, et al., "The Effect of Intracameral Ethacrynic Acid on Introcular Pressure of Living Monkeys".
The Assoc. for Research in Vision and Ophthalmology ARVO 1989, Nos. 68 and 70, p. 356: Patel, et al., "Interactions of Ethacrynic Acid and Other Sulfhydryl Agents with Proteins in the Calf Trabecular Meshwork"; Schroeder, et al., Ethacrynic Acid Induced Changes in Cytoskeletal Tubulin.
The Assoc. for Research in Vision and Ophthalmology ARVO 1990, No. 1849, p. 376: Liang, et al., "Ethacrynic Acid Increases Facility of Outflow in the Human Eye In Vitro".
Chemical Abstracts, "N-Argylglycines", Merck & Co., Inc., Neth. Appl. 6,502,404, vol. 64, No. 6, col. 8093 (1966).
Chemical Abstracts, "[[4-(2-Methylenealkanoyl)phenyl]sulfinyl]alkanecarboxylic acids", Merck & Co., Inc., Neth. Appl. 6,506,045, vol. 65, col. 654 (1966).
Alcon Laboratories Inc.
Brown Gregg C.
Dees Jos,e G.
Jones Dwayne C.
Mayo Michael C.
LandOfFree
Ethacrynic acid-like compounds and use thereof to treat glaucoma does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ethacrynic acid-like compounds and use thereof to treat glaucoma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ethacrynic acid-like compounds and use thereof to treat glaucoma will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1560873