Eszopiclone process

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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C544S336000

Reexamination Certificate

active

08058438

ABSTRACT:
Eszopiclone is prepared by reacting zopiclone with an enatiomerically pure di-p-toluoyl tartaric acid, recovering a solid salt, and reacting a solid salt with a base. Zopiclone is prepared by reacting 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]-pyrazine with 1-chlorocarbonyl-4-methylpiperazine hydrochloride.

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patent: 6339086 (2002-01-01), Jerussi et al.
patent: 6444673 (2002-09-01), Cotrel et al.
patent: 7476737 (2009-01-01), Mandava et al.
patent: 7772396 (2010-08-01), Bleda et al.
patent: 7786304 (2010-08-01), Sawant et al.
patent: 2005/0043311 (2005-02-01), Cotrel et al.
patent: 2007/0203145 (2007-08-01), Zhu
patent: 00/69442 (2000-11-01), None
patent: 2007/083188 (2007-07-01), None

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