Estrone sulfamate inhibitors of estrone sulfatase, and associate

Details Estrone sulfamate inhibitors of estrone sulfatase, and associate Estrone sulfamate inhibitors of estrone sulfatase, and associate

1997-12-24

2000-04-04

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514176, 514179, 514182, 540113, 552502, 552515, 552531, 552540, 552543, 552544, 552548, 552552, 552553, 552555, 552556, 552558, 552618, 552626, 552650, 552652, A61K 3156, A61K 3158, C07J 4300, C07J 900

Patent

active

060461861

ABSTRACT:
Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) wherein r1 is an optional double bond, R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen and lower alky, or together form a cyclic substituent (II) ##STR1## wherein Q is NH, O or CH.sub.2, and the other various substituents are as defined herein. Pharmaceutical compositions and methods for using the compounds of formula (I) to treat estrogen-dependent disorders are provided as well.

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