Estrogenic compounds as anti-mitotic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Reexamination Certificate

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C514S559000, C514S661000, C514S719000, C514S730000, C514S738000, C568S817000, C568S941000, C568S665000, C568S023000, C564S458000, C562S498000, C560S116000

Reexamination Certificate

active

06930128

ABSTRACT:
The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.

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