Estrogenic compounds as anti-mitotic agents

Details Estrogenic compounds as anti-mitotic agents Estrogenic compounds as anti-mitotic agents

1995-12-12

1997-08-26

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514178, 514179, 514180, 514177, A61K 3156

Patent

active

056611439

ABSTRACT:
The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.

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patent: 4522758 (1985-06-01), Ward et al.
patent: 4743597 (1988-05-01), Javitt et al.
patent: 5001116 (1991-03-01), Folkman et al.
Seegers et al, J. Steroid, Biochem. vol. 32 No. 6 pp. 797-809, 1989.
Wheeler et al, Mutation Research, 171 (1986) 31-41.

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