Estrogenic compounds as anti-mitotic agents

Details Estrogenic compounds as anti-mitotic agents Estrogenic compounds as anti-mitotic agents

1997-04-25

1999-04-06

Cook, Rebecca

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552515, 552522, 552523, 552524, 552525, 552613, 552614, 552617, 552618, 552619, 552620, 552624, 552625, 552626, 552650, 552651, 552652, C07J 100

Patent

active

058920692

ABSTRACT:
The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.

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CA 117:245769, Lottering et al, 1992.
CA 111: 50609, Spicer et al, 1989.
CA 109: 32325, Adams et al, 1988.
CA 105: 54822, Wheeler et al, 1986.
CA 102: 143342,Mukundan et al, 1984.
CA 98: 31837, Bhat et al, 1982.
CA 94: 114277, Blickenstaff, 1979.
CA 85: 172 052, Morgan et al, 1976.

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