Combinatorial chemistry technology: method – library – apparatus – Library – per se
Reexamination Certificate
2008-05-13
2008-05-13
Schultz, J. Douglas (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Library, per se
C435S006120, C536S023100, C536S024310, C536S023500, C506S009000
Reexamination Certificate
active
10511064
ABSTRACT:
A plurality of genes modulated by estrogen or other agents, such as hormones or combinations of hormones, in various types of tissue is described. One embodiment of the disclosure relates to a plurality of genes, which demonstrates certain patterns of expression differing qualitatively or quantitatively, with and without exposure to estrogen and/or other hormone compositions. Methods of using these genes in identifying candidate agents that exert at least some of the biological effects of estrogen and/or other hormone, and pharmaceuticals and related therapies also is disclosed. The use of the plurality of genes in methods of monitoring, in gene chips and in kits also is disclosed.
REFERENCES:
patent: 5508164 (1996-04-01), Kausch
patent: 5747253 (1998-05-01), Ecker et al.
Melia et al., Endocrinology 139(2):688-695 (1998).
Chern et al., Nephron 85:258-266 (2000).
Kuiper et al., Frontiers in Neuroendocrinology 19:253-286 (1998).
Grodstein, F., Manson, J.E., Colditz, G A., Willett, W. C., Speizer, F. E. & Stampfer, M. J. (2000); A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Annals of Internal Medicine 133, 933-41.
Barrett-Connor, E., Slone, S., Greendale, G., Kritz-Silverstein, D., Espeland, M., Johnson, S. R., Waclawiw, M. & Fineberg, S. E. (1997); The postmenopausal estrogen/progestin interventions study: primary outcomes in adherent women. Maturitas 27, 261-74.
Godsland, I. F. (2001); Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974-2000. Fertility & Sterility 75, 898-915.
Nanda, K., Bastian, L. A., Hasselblad, V. & Simel, D. L. (1999); Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis. Obstetrics & Gynecology 93, 880-8.
Kawas, C., Resnick, S., Morrison, A., Brookmeyer, R., Corrada, M., Zonderman, A., Bacal, C., Lingle, D. D. & Metter, E. (1997); A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology 48, 1517-21.
Worzala, K., Hiller, R., Sperduto, R. D., Mutalik, K., Murabito, J. M., Moskowitz, M., D'Agostino, R. B. & Wilson, P. W. (2001); Postmenopausal estrogen use, type of menopause, and lens opacities: the Framingham studies. Archives of Internal Medicine 161, 1448-54.
Kuiper, & G, Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S. & Gustafsson, J. A. (1997) Endocrinology 138, 863-70.
Hill, A. A., Hunter, C. P., Tsung, B. T., Tucker-Kellogg, G & Brown, E. L. (2000); Genomic analysis of gene expression inC. elegans, Science 290, 809-12.
Shughrue, P., Scrimo, P., Lane, M., Askew, R. & Merchenthaler, I. (1997): The distribution of estrogen receptor-beta mRNA in forebrain regions of the estrogen receptor-alpha knockout mouse. Endocrinology 138, 5649-52.
Evans, M. J., Eckert, A., Lai, K., Adelman, S. J. & Hamish, D. C. (2001); Reciprocal antagonism between estrogen receptor and NF-kappaB activity in vivo. Circulation Research 89, 823-830.
Kraichely, D. M., Sun, J., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. (2000); Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 141, 3534-45.
Lubahn, D. B., Moyer, J. S., Golding, T. S., Couse, J. F., Korach, K. S. & Smithies, O. (1993); Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proceedings of the National Academy of Sciences of the United States of America 90, 11162-6.
Pendaries, C., Darblade, B., Rochaix, P., Krust, A., Chambon, P., Korach, K. S., Bayard, F. & Arnal, J. F. (2002); The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice. Proceedings of the National Academy of Sciences of the United States of America 99, 2205-2210.
Couse, J. F., Curtis, S. W., Washburn, T. F., Lindzey, J., Golding, T. S., Lubahn, D. B., Smithies, O. & Korach, K. S. (1995); Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Molecular Endocrinology 9, 1441-54.
Berry, M., Metzger, D. & Chambon, R (1990); Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO Journal 9, 2811-8.
Hall, J. M. & McDonnell, D. P. (1999); The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140, 5566-78.
Weihua, Z., Saji, S., Makinen, S., Cheng, G., Jensen, E. V., Waamer, M. & Gustafsson, J. A. (2000); Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus. Proceedings of the National Academy of Sciences of the United States of America 97, 5936-41.
Trogan, E., Choudhury, R. P., Dansky, H. M., Rong, J. X., Breslow, J. L. & Fisher, E. A. (2002); Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 99, 2234-2239.
Evans, M. J., Lai, K., Shaw, L. J., Harnish, D. C. & Chadwick, C. C. (2002); Estrogen receptor alpha inhibits IL-1beta induction of gene expression in the mouse liver. Endocrinology, 143(7):2559-70.
McIntire, J. J., Umetsu, S. E., Akbari, O., Potter, M., Kuchroo, V. K., Barsh, G. S., Freeman, Q J., Umetsu, D. T. & DeKruyff, R. H. (2001); Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nature Immunology 2, 1109-16.
Ichimura, T., Bonventre, J. V., Bailly, V., Wei, H., Hession, C. A., Cate, R. L. & Sanicola, M. (1998): Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. Journal of Biological Chemistry 273, 4135-42.
Davidoff, M., Caffier, H. & Schiebler, T. H. (1980); Steroid hormone binding receptors in the rat kidney. Histochemistry 69, 39-48.
Aitken, J. M., Lindsay, R. & Hart, D. M. (1974); The redistribution of body sodium in women on long-term oestrogen therapy. Clinical Science-& Molecular Medicine 47, 179-87.
Pirani, B. B., Campbell, D. M. & MacGillivray, I. (1973); Plasma volume in normal first pregnancy. Journal of Obstetrics & Gynaecology of the British Commonwealth 80, 884-7.
Stachenfeld, N. S., DiPietro, L., Palter, S. F. & Nadel, E. R. (1998); Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women. American Journal of Physiology 274, R187-95.
Verlander, J. W., Tran, T M., Zhang, L., Kaplan, M. R. & Hebert, S. C. (1998); Estradiol enhances thiazide-sensitive NaCl cotransporter density in the apical plasma membrane of the distal convoluted tubule in ovariectomized rats. Journal of Clinical Investigation 101, 1661-9.
Farmer, M. K., Robbins, M. J., Medhurst, A. D., Campbell, D. A., Ellington, K., Duckworth, M., Brown, A. M., Middlemiss, D. N., Price, G. W. & Pangalos, M. N. (2000); Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl−—dependent neurotransmitter transporter gene family. Genomics 70, 241-52.
Reddy, M. M., Light, M. J. & Quinton, P. M. (1999); Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl− channel function. Nature 402, 301-4.
Fu, G. K., Lin, D., Zhang, M. Y., Bikle, D. D., Shackleton, C. H., Miller, W. L. & Portale, A. A. (1997); Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-depend
Brown Eugene Lee
Evans Mark James
Frail Donald Edward
Harris Heather Anne
Jelinsky Scott Alan
Darby & Darby P.C.
Lundgren J. S.
Schultz J. Douglas
Wyeth
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