Estrogen receptor regulation and its uses

Details Estrogen receptor regulation and its uses Estrogen receptor regulation and its uses

1994-06-16

1996-10-08

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, C12Q 168, G01N 3353

Patent

active

055630359

ABSTRACT:
ERF-1 is shown to be a transcriptional regulator of the expression of the estrogen receptor, where elevated ERF-1 is related to elevated expression of the estrogen receptor. By monitoring the level of ERF-1, one can relate phenotypic characteristics of carcinomas expressing ERF-1 as prognostic of the response of the tumor to various therapies. In addition, ERF-1 may be used for screening therapeutic drugs which may act as antagonists to initiation of estrogen receptor transcription.

REFERENCES:
Weigel et al, Cancer Research (1993); vol. 53: pp. 3472-3474.
Hakim, "Prognostic Significance of mRNA-Encoding Estrogen Receptor and Epithelial Growth Factor Receptor in Breast Carcinoma Progression into Lymph Nodes: 1. Estrogen Receptor Encoding mRNA," J. Surg. Oncology (1989) 40:21-31.

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