Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Reexamination Certificate
2005-01-04
2005-01-04
Barts, Samuel (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
C568S721000, C546S038000, C546S195000, C514S279000, C514S732000, C514S738000
Reexamination Certificate
active
06838584
ABSTRACT:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
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Rama Rao, et al., “Synthesis of spiro[4,4]nonane system present in fredericamycin A+”, Ind. Jour. Chem. Aug. 1991, vol. 30B, pp. 723-727.
Rama Rao, et al., “Palladium (II)-mediated Synthesis of spiro[4,4]nonane System Present in Fredericamycin A”, Ind. Journ. Chem. Dec. 1988, vol. 27B, pp. 1065-1066.
Kessar, et al., “y-Alkoxylactones as Autounmasking Synthons for a One-step Construciton of 1,3-Oxygenated Cyclopentanes . . . ”, J. Chem. Soc., Chem. Commun 1994, pp. 1327-1328.
Blizzard Timothy Allen
Hammond Milton Lloyd
Morgan Jerry Dwain
Mosley Ralph Troy
Barts Samuel
Beeler Nicole M.
Daniel Mark R.
Merck & Co. , Inc.
Witherspoon Sikarl A.
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