Estrogen receptor modulators

Details Estrogen receptor modulators Estrogen receptor modulators

2011-04-12

2011-04-12

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S259000, C548S261000, C548S358500, C514S359000, C514S406000

Reexamination Certificate

active

07923568

ABSTRACT:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.

REFERENCES:
patent: 7087599 (2006-08-01), Parker, Jr. et al.
patent: WO0241835 (2002-05-01), None
patent: WO2006062876 (2006-06-01), None
Golub et al, Science (1999) vol. 286, pp. 531-537.
Gallinari et al, Chemistry & Biology, vol. 12, pp. 883-893 (2005).

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