Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-04-08
2008-04-08
Shukla, Ram R. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200
Reexamination Certificate
active
07354712
ABSTRACT:
In one aspect, the present invention provides methods of determining susceptibility to bone fracture in a mammalian subject, wherein the methods comprise analyzing nucleic acid molecules obtained from the mammalian subject to determine which of the P, p X, and x alleles of the estrogen receptor α gene are present, wherein the presence of a haplotype comprising the p and x alleles is indicative of an increased susceptibility to bone fracture. The present invention also provides kits for determining susceptibility to bone fracture in a mammalian subject.
REFERENCES:
patent: 4529593 (1985-07-01), Warrell et al.
patent: 5593833 (1997-01-01), Morrison et al.
patent: 5939260 (1999-08-01), Spector et al.
patent: WO 94/03633 (1994-02-01), None
patent: WO 97/40187 (1997-10-01), None
Aerssens et al. 2000 Osteoporos International vol. 11 p. 583.
Kobayasi et al 2002 Maturitas vol. 41 p. 193.
Van Meurs et al. 2003 Human Molecular Genetics vol. 12 p. 1745.
Uitterlinden et al. 2001 Journal of Bone and Mineral Research vol. 16 p. 379.
Wiling et al. 1998 Journal of Bone and Mineral Research vol. 13 p. 695.
Chango, A., et al., “5,10-Methylenetetrahydrofolate Reductase Common Mutations, Folate Status and Plasma Homocysteine in Healthy French Adults of the Supplementation en Vitamines et Mineraux Antioxydants (SU.VI.MAX) Cohort,”British Journal of Nutrition 84:891-896, 2000.
Christensen, B., et al., “Correlation of a Common Mutation in the Methylenetetrahydrofolate Reductase Gene With Plasma Homocysteine in Patients With Premature Coronary Artery Disease,”Arteriosclerosis, Thrombosis, and Vascular Biology 17(3):569-573, Mar. 1997.
Cooper, G.S. and D.M. Umbach, “Are Vitamin D Receptor Polymorphisms Associated With Bone Density?, A Meta-Analysis,”J. Bone Miner. Res. 11:1841-1849, 1996.
Goyette, P., et al., “Human Methylenetetrahydrofolate Reductase: Isolation of cDNA, Mapping and Mutation Identification,”Nature Genetics 7:195-200, Jun. 1994.
Goyette, P., et al., “Gene Structure of Human and Mouse Methylenetetrahydrofolate Reductase (MTHFR),”Mammalian Genome 9:652-656, 1998.
Grant, S.F.A., et al., “Reduced Bone Density and Osteoporosis Associated With a Polymorphic Sp1 Binding Site in the Collagen Type Iα1 Gene,”Nature Genetics 14:203-205, Oct. 1996.
Hofman, A., et al., “Determinants of Disease and Disability in the Elderly: The Rotterdam Elderly Study,”Eur. J. Epidemiol. 7(4):403-422, Jul. 1991.
Houston, L.A., et al., “Vitamin D Receptor Polymorphism, Bone Mineral Density, and Osteoporotic Vertebral Fracture: Studies in a UK Population,”Bone 18(3):249-252, 1996.
Ioannidis, J.P.A., et al., “Association of Polymorphisms of the Estrogen Receptor Alpha Gene With Bone Mineral Density and Fracture Risk in Women: A Meta-Analysis,”J. Bone Miner. Res. 17(11):2048-2060, 2002 [Abstract].
Mann, V., et al., “ACOL1A1Sp1 Binding Site Polymorphism Predisposes to Osteoporotic Fracture by Affecting Bone Density and Quality,”J. Clin. Invest. 107(7):899-907, Apr. 2001.
Miyao, M., et al., “Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism With Bone Mineral Density in Postmenopausal Japanese Women,”Calcified Tissue Int'l 66:190-194, 2000.
Moritsugu, K.P., et al., “Report of the Surgeon General's Workshop on Osteoporosis and Bone Health,”Proceedings of the Surgeon General's Workshop on Osteoporosis and Bone Health, Washington, D.C., Dec. 12-13, 2002, pp. 1-55.
Morrison, N.A., et al., “Prediction of Bone Density From Vitamin D Receptor Alleles,”Nature 367:284-287, 1994.
Ralston, S.H., “Genetic Markers of Bone Metabolism and Bone Disease,”Scand. J. Clin. Lab. Invest. 57(Suppl. 227):114-121, 1997.
Ralston, S.H., “The Genetics of Osteoporosis,”Q.J. Med. 90:247-251, 1997.
Uitterlinden, A.G., et al., “Interaction Between the Vitamin D Receptor Gene and Collagen Type Iα1 Gene in Susceptibility for Fracture,”J. Bone Miner. Res. 16:379-385, 2001 [Abstract].
Uitterlinden, A.G., et al., “A Large-Scale Population-Based Study of the Association of Vitamin D. Receptor Gene Polymorphisms With Bone Mineral Density,”J. Bone Miner. Res. 11(9):1241-1248, 1996.
Uitterlinden, A.G., et al., “Relation of Alleles of the Collagen Type Iα1 Gene to Bone Density and the Risk of Osteoporotic Fractures in Postmenopausal Women,”New Engl. J. Med. 338(15):1016-1021, Apr. 9, 1998.
Uitterlinden, A.G., et al., “Sp1 Binding Site Polymorphism in the COLIA1 Gene Is Associated With BMD: The Rotterdam Study,”Osteoporosis Int'l, 6(1):124, PSu164, 1996 [Abstract].
Uitterlinden, A.G., Ph.D., et al., “Vitamin D Receptor Genotype Is Associated With Radiographic Osteoarthritis at the Knee,”J. Clin. Invest. 100(2):259-263, 1997.
Van der Klift, M., et al., “The Incidence of Vertebral Fractures in Men and Women: The Rotterdam Study,”J. Bone Miner. Res. 17(6):1051-1056, 2002 [Abstract].
White, C.P., et al., “Vitamin D Receptor Alleles Predict Osteoporotic Fracture Risk,”J. Bone Miner. Res. 9(suppll):S263, 1994 [Abstract].
Willing, M., et al., “Bone Mineral Density and its Change in White Women: Estrogen and Vitamin D Receptor Genotypes and Their Interaction,”J. Bone Miner. Res. 13(4):695-705, 1998 [Abstract].
Pols Huibert Adriaan Pieter
Uitterlinden Andreas Gerardus
Van Leeuwen Johannes Petrus Thomas Maria
Century Technology, Inc.
Salmon Katherine
Sheridan & Ross P.C.
Shukla Ram R.
LandOfFree
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