Surgery – Diagnostic testing – Liquid collection
Patent
1998-02-26
1999-11-09
Hindenburg, Max
Surgery
Diagnostic testing
Liquid collection
A61B 500
Patent
active
059804700
ABSTRACT:
Maternal blood unconjugated estriol is used to determine whether steroid treatment has or has not effectively accelerated fetal lung maturation and reduced the risk of RDS. A blood sample is obtained from the mother prior to treating her with steroids and again 24 hours later. The blood cells are separated from the serum and the serum is analyzed for unconjugated estriol concentration in the two blood samples obtained. If the percent change in the estriol concentration of the mother's blood decreases by a significant percentage over the 24 hour period from the start of the steroid treatment, the infant will not develop RDS. If the percent change in the estriol concentration of the mother's blood does not decrease by a significant percentage over the 24 hour period from the start of the steroid treatment, the infant will be at the same risk of RDS as it would have been without the steroid treatment. The information obtained from this test is used to make decisions regarding further treatment.
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Kauppila, Antti, et al., "Effect of Dexamethasone on Blood Levels of ACTH, Cortisol, Progesterone, Estriol and Estriol during Late Pregnancy," Int. J. Gynaecol Obstet 14:177-181, 1976.
Friedrich, F., et al., "Betamethasontest zur Diagnose der Plazentainsuffizienz," Symposium der Deutschen Gesellschaft fur Endokrinologie, Feb. 24-27/1982.
Kappy, Kenneth A., et al., "Betamethasone and the Hormonal Status of the Pregnant Diabetic Woman," Int J Gynaecol Obstet 17:465-466, 1980.
Whitt, Gerald G., et al., "A Comparison of Two Glucocorticoid Regimens for Acceleration of Fetal Lung Maturation in Premature Labor," Am. J. Obstet. Gynecol., vol. 124, No. 5, 479-482, 1976.
Kjer, J.J., et al., "Serum Estriol Level during Treatment with Betamethasone in the Last Trimester of Human Pregnancy," Acta Obstet Gynecol Scand, 62:307-309, 1983.
Creighton Wray James
Hindenburg Max
Narasimhan Meera P.
ProBiotix, Inc.
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