Estradiol derivative-alkylating agent conjugate with reduced hor

Details Estradiol derivative-alkylating agent conjugate with reduced hor Estradiol derivative-alkylating agent conjugate with reduced hor

1994-09-26

1995-12-26

Kestler, Kimberly J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552613, 552614, 552618, 552626, C07J 100, A61K 31565

Patent

active

054788188

ABSTRACT:
Disclosed is an estradiol derivative-alkylating agent conjugate of the formula (I'): ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer of 0 to 3, which is useful a growth inhibiting agent.

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Pharmazie 38 (1983), H. 7 pp. 445-448 Mohsen et al Steroidal Derivatives "Synthesis and in vitro Anabolic and Catabolic Properties of a New Group of Steroidal Alkylating Agents".
J. Steroid Biochem. vol. 29, No. 6, pp. 657-664, 1988 Qian et al "Synthesis and Biological Activity of 17.beta.-Substituted Estradiol".

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