Estradiol compositions and methods for topical application

Details Estradiol compositions and methods for topical application Estradiol compositions and methods for topical application

1992-04-14

1993-08-03

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424 45, 424447, 424448, 514944, 514946, 514947, 239338, A61F 1300

Patent

active

052327035

ABSTRACT:
A mixture of estradiol or other estrogen and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer provides a matrix which gradually releases the medicament upon application to the skin of a patient in the form of an ointment, gel or film. The polymer provides for the slow and sustained release of the medicament upon topical application to the skin so that the concentration of drug in the blood plasma of the patient is maintained within the levels required for clinical efficacy.

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