Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1978-11-29
1981-08-18
Hunt, Brooks H.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
424 9, 424 1, 560 8, 560106, A61K 4900, A61K 4300, C07C 6976
Patent
active
042846196
ABSTRACT:
Certain radioiodine containing esters useful as brain imaging agents are disclosed. The compounds of the subject invention are represented by the formula ##STR1## wherein I is a radioisotope of iodine with iodine-123 being preferred and R is selected from the group consisting of alkyl, aryl, substituted aryl, aralkyl, a polyhydric alcohol radical and a 5- or 6-membered heterocyclic ring.
REFERENCES:
patent: 3144479 (1964-08-01), Obendorf
patent: 3317569 (1967-05-01), Larsen et al.
Tubis et al., Int. J. Appl. Rad. Isot., 15:397-400, (1964).
Elias et al., Int. J. Appl. Rad. Isot., 24:463-469, (1973).
Blav et al., Int. J. Appl. Rad. Isot., 3:217-225, (1958).
Hansen et al., J. Med. Chem., 21:830-833, (1978).
Holman et al., T. Lab. Comp. Radiopharm, 16:69-71, (1979).
Epstein William H.
Gould George M.
Hunt Brooks H.
Medi--Physics, Inc.
Nucker Christine M.
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