Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3

Details Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3 Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3

1982-09-09

1984-10-16

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, C07D22316, A61K 3155

Patent

active

044773781

ABSTRACT:
Disclosed are esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1-H-3-benzazepines represented by the general formula I ##STR1## wherein X is chloro, bromo or trifluoromethyl; R.sub.1 is alkyl, aralkyl, aryl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, cycloalkylalkyl, alkoxycarbonylalkyl, cycloalkyl, 1-adamantyl, cycloalkoxyalkyl, alkoxy, aralkoxy, cycloalkoxy or aryloxy; and the pharmaceutically acceptable acid addition salts thereof. The compounds show neuroleptic, antidepressive and antiaggressive activity.

REFERENCES:
patent: 3393192 (1968-07-01), Walter et al.
patent: 3409607 (1968-11-01), Fujimura et al.
patent: 3483185 (1969-12-01), Tokolics et al.
patent: 3686167 (1972-08-01), Fujimura et al.
patent: 4104379 (1978-08-01), Gallagher et al.
patent: 4197297 (1980-04-01), Weinstock

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