Esters of pyridine-2,4- and 2,5-dicarboxylic acid as medicaments

Details Esters of pyridine-2,4- and 2,5-dicarboxylic acid as medicaments Esters of pyridine-2,4- and 2,5-dicarboxylic acid as medicaments

1985-08-29

1988-01-05

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514801, 514855, A61K 3144

Patent

active

047177276

ABSTRACT:
Esters of pyridine-2,4- and -2,5-dicarboxylic acid act as inhibitors of proline hydroxylase and lysine hydroxylase and are suitable as fibrosuppressants and immunosuppressants, in particular for the treatment of disturbances of the metabolism of collagen and collagen-like substances and of the biosynthesis of Cl.sub.q.

REFERENCES:
patent: 2809146 (1957-10-01), Osborn et al.
patent: 2852519 (1958-09-01), Kruse
patent: 4457936 (1984-07-01), Draeger et al.
Burger's Medicinal Chemistry, 4th ed., Part II, Ed. by M. Wolff, pp. 1242-1244, 1978.
Muller et al., "Reversible Inhibition of ClQ Release from Guinea Pig Microphages by 2,2'-Dipyridyl".
Majamaa et al., "The 2-Oxoglutarate Binding Site of Prolyl 4-Hydroxylase.
Gunzler et al., "Influence of the Posttransitional Hydroxylation Step on the Secretion of Cl9, a Subcomponent of the First Component of a Complement by Macrophages".
Pliml, Synthetic Analogs of Curare Alkaloids, Chemical Abstracts 9665 f, 1955.

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