Esters of p-hydroxyaniline mustard

Details Esters of p-hydroxyaniline mustard Esters of p-hydroxyaniline mustard

1995-02-27

1996-12-17

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 60, 560110, C07C26100, C07C26900, C07C 6976

Patent

active

055855121

ABSTRACT:
There is disclosed an ester compound that is resistant to decomposition in blood, but is quickly hydrolyzed in cancer cells, and functions as an anticancer agent. The ester compound has a structure represented by formula (I) or formula (II): ##STR1## wherein R.sub.1 represents a methyl group, a methoxy group, or a trifluoroacetamido group; R.sub.2 represents a phenyl group or a phenylmethyl group; and the absolute configuration of the asymmetric center marked with an asterisk is R.

REFERENCES:
patent: 3592949 (1971-07-01), Teach et al.
patent: 3670010 (1972-06-01), Teach
patent: 3792994 (1974-02-01), Baker et al.
patent: 4282368 (1981-08-01), Merger et al.
A Collection of the Substance of a Lecture, p. 36, vol. 4, Mar. 5, 1994.

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