Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1986-03-17
1987-11-03
Lone, Werren B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
562449, C07C101447
Patent
active
047044683
ABSTRACT:
This invention relates to biologically active esters of 0(2,6-dichlorophenylamino) phenylacetic acid and a method for their preparation. The inventive esters have the formula ##STR1## wherein R represents a hydroxyl group or the radical ##STR2## and n is an integer from 10-450. The molecular mass of the inventive compounds ranges from 700-30,000, as determined by the vapor pressure method. The inventive compounds may be prepared by reacting 0(2,6-dichlorophenylamino) phenylacetic acid with polyethyleneglycols having the formula HO (CH.sub.2 --CHO.sub.2).sub.n H, where n is as defined above, in the presence of an acid and while heated in an inactive solvent. The inventive compounds exhibit a high antiphlogistic activity, but are much less irritating to the stomach mucosa then the prior art compounds.
REFERENCES:
patent: 3511872 (1970-05-01), Sherlock
patent: 3558690 (1971-01-01), Sallmann et al.
patent: 4189595 (1980-02-01), Sakoda et al.
patent: 4375478 (1983-03-01), Horrom et al.
patent: 4548952 (1985-10-01), Casas
Ivanova Nedyalka S.
Nikolova Milka P.
Ognyanova Vaska A.
Petrova Lyudmila V.
Tanev Georgi L.
Clarke Vera C.
Lone Werren B.
T P O "Pharmachim"
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