Esters of N-alkyl-nortropines and their quaternary derivatives h

Details Esters of N-alkyl-nortropines and their quaternary derivatives h Esters of N-alkyl-nortropines and their quaternary derivatives h

1987-02-09

1988-10-25

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546127, C07D45106, A61K 3146

Patent

active

047804670

ABSTRACT:
The esters of N-alkyl-nortropines with phenyl-cyclohexen-carboxylic and phenyl-cyclohexen-acetic acids and their quaternary ammonium derivatives with alkyl halides and alkyl sulphates having general formula: ##STR1## whereas R'=-, --H, --CH.sub.3, --CH.sub.2 --CH.sub.3, --CH.sub.2 --CH.sub.2 --CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.3, --CH.sub.2 CH--(CH.sub.3).sub.2
X.sup.- =Cl, Br, I, CH.sub.3 SO.sub.4
show anti-bronchospastic activity. The invention relates also to the processes for their preparation and to the pharmaceutical compositions containing them.

REFERENCES:
patent: 2706198 (1955-04-01), Weijlard

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