Esters of L-carnitine of alkanoyl L-carnitines useful as...

Details Esters of L-carnitine of alkanoyl L-carnitines useful as... Esters of L-carnitine of alkanoyl L-carnitines useful as...

2003-07-23

2009-12-08

Kishore, Gollamudi S (Department: 1612)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

Reexamination Certificate

active

07629003

ABSTRACT:
Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.

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Wang, Jinkang et al; Synthesis and Characterization of Long Chain Alkyl Acyl Carnitine Ester. Potentially Biodegradable Cationic Lipids for Use In Gene Delivery; J. Med. Chem. (1998), 41(13), 2207-2215, cited in the application p. 2208.

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