Esters of indole-1-acetic acid and analgesic use thereof

Details Esters of indole-1-acetic acid and analgesic use thereof Esters of indole-1-acetic acid and analgesic use thereof

1978-05-09

1980-11-11

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

26032614R, 26032613R, 544143, 544373, 546201, 424267, 424251, 42424855, A61K 3140, C07D20920

Patent

active

042333121

ABSTRACT:
Novel indoles of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, halogen, --CF.sub.3, alkyl of 1 to 8 carbon atoms and alkoxy of 1 to 8 carbon atoms, R.sub.2 is in the 2, 3 or 4 position and is selected from the group consisting of halogen, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 8 carbon atoms, A is selected from the group consisting of branched alkylene of 3 to 5 carbon atoms and --(CH.sub.2).sub.n -- and n is a number of 2 to 5 and R.sub.3 and R.sub.4 are alkyl of 1 to 8 carbon atoms or taken together with the nitrogen atom form a heterocyclic ring selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, piperazinyl and N-alkyl piperazinyl with 1 to 4 alkyl carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic activity and their preparation.

REFERENCES:
patent: 2930798 (1960-03-01), Schmitt
patent: 3047584 (1962-07-01), Elkin
patent: 3557142 (1971-01-01), Bell
patent: 3856967 (1974-12-01), Allais et al.
patent: 4021448 (1977-05-01), Bell
Chem. Abst., 83, 131,402u (1975), Abst. of Allais et al., Eur. J. Med. Chem.-Chim. Ther., 10, pp. 187-199 (1975).

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