Esters of hyaluronic acid with rhein, process for their...

Details Esters of hyaluronic acid with rhein, process for their... Esters of hyaluronic acid with rhein, process for their...

2005-02-25

2010-11-16

Maier, Leigh C (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S055100

Reexamination Certificate

active

07834173

ABSTRACT:
The present invention relates to esters of hyaluronic acid with rhein, more particularly to a compound based on hyaluronic acid, wherein alcohol groups of hyaluronic acid are esterified with rhein, to a process for preparing said ester and to a pharmaceutical composition comprising said ester.

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Smith, G. et al “Diacerhein treatment reduces the severity of osteoarthritis . . . ” Arthritis Rheum. (1999) vol. 42, No. 3, pp. 545-554.
Moreland, L. “Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis . . . ” Arthritis Res. Ther. (2002) vol. 5, pp. 54-67.
“Effect of Diacetyl Rhein on the Development of Experimental Osteoarthritis a Biochemical Investigation” by S.L. Carney; Dec. 1996; Osteoarthritis and Cartilage;Bailliere Tindall, London, GB; pp. 251-261; XP001056066; ISSN: 1063-4584; abstract.
“Hyaluronic Acid Hydrogel in the Treatment of Osteoarthritis” by R. Barbucci et al.; Dec. 2002; Biomaterials; Elsevier Science Publishers BV., Barking, GB; pp. 4503-4513; XP004377521; ISSN: 0142-9612; abstract.

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