Esters of disubstituted isobutyric acids and pharmaceutical comp

Details Esters of disubstituted isobutyric acids and pharmaceutical comp Esters of disubstituted isobutyric acids and pharmaceutical comp

1977-11-11

1979-02-13

Raymond, Richard

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

2603474, 2603475, 42424855, 424250, 544152, 544379, A61K 3134, C07D30716

Patent

active

041396316

ABSTRACT:
Pharmacologically valuable esters of isobutyric acid have the general formula ##STR1## in which R is biphenylyl, norbornyl or para-cyclohexylphenyl and R.sup.1 and R.sup.2 are each lower alkyl groups or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are linked is a saturated heterocyclic group which may contain an additional hetero atom. The esters may be used in the form of their salts with pharmaceutically acceptable acids.
The esters and their salts possess spasmolytic and vasodilatory activity and are useful in the treatment of arterial disorders.

REFERENCES:
patent: 3334096 (1967-08-01), Szarvasi et al.
patent: 3872112 (1975-03-01), Szarvasi
Moffett et al., J. Am. Pharm. Assoc. Ed. Sci., vol. 42 (1953) pp. 717-719.

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