Esters of castanospermine in the treatment of cerebral malaria

Details Esters of castanospermine in the treatment of cerebral malaria Esters of castanospermine in the treatment of cerebral malaria

1992-03-05

1993-05-25

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A01N 4342, A61K 3144

Patent

active

052140504

ABSTRACT:
Red blood cells which are infected with the parasite P. falciparum cause the cells to become sticky and less deformable. This results in a build-up of cells on the vascular wall and creates occlusions to blood flow which are thought to cause the cerebral, renal and liver complications of P. falciparum infections. Certain esters of castanospermine prevent or reduce the adhesion of falciparum infected blood cells to the vascular endothelial wall and are a useful adjunct in the treatment of malaria.

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