Esters of 5-aminolevulinic acid as photosensitizing agents...

Special receptacle or package – Combined or convertible – Packaged assemblage or kit

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S551000, C560S155000

Reexamination Certificate

active

07850008

ABSTRACT:
The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

REFERENCES:
patent: 4087532 (1978-05-01), Merz et al.
patent: 4575515 (1986-03-01), Sandborn
patent: 5079262 (1992-01-01), Kennedy et al.
patent: 5211938 (1993-05-01), Kennedy et al.
patent: 5219878 (1993-06-01), Ringuet et al.
patent: 5234940 (1993-08-01), Kennedy et al.
patent: 5422093 (1995-06-01), Kennedy et al.
patent: 5661111 (1997-08-01), Kuramochi et al.
patent: 5955490 (1999-09-01), Kennedy et al.
patent: 6034267 (2000-03-01), Gierskcky et al.
patent: 6492420 (2002-12-01), Gierskcky et al.
patent: 24 11 382 (1975-09-01), None
patent: 0316179 (1989-05-01), None
patent: 1 496 418 (1977-12-01), None
patent: 2 058 077 (1981-04-01), None
patent: 197211 (1990-01-01), None
patent: 900287712 (1992-04-01), None
patent: 05137587 (1993-06-01), None
patent: 06141681 (1994-05-01), None
patent: 07 053487 (1995-02-01), None
patent: 08151304 (1996-06-01), None
patent: 11012197 (1999-01-01), None
patent: 11028084 (1999-02-01), None
patent: 11171852 (1999-06-01), None
patent: 2000023691 (2000-01-01), None
patent: WO 91/01727 (1991-02-01), None
patent: WO 92/06097 (1992-04-01), None
patent: WO 93/20810 (1993-10-01), None
patent: WO 95/07077 (1995-03-01), None
patent: WO 96/06602 (1996-03-01), None
patent: WO 96/28412 (1996-09-01), None
K. Syanberg et al., “Photodynamic therapy of non-melanoma malignant tumours of the skin using topical ç-amino levulinic acid sensitization and laser irradiation,” British Journal of Dermatology (1994) vol. 130, pp. 743-751.
R. Bachor et al., “Photodynamic Therapy using Aminolevulinic Acid (ALA),” Univ. Of Ulm, Dept. of Urology, 7900 Ulm, Germany, SPIE, vol. 2078, pp. 372-380.
C. Abels, “In vivo kinetics and spectra of 5-aminolaevulinic acid-induced fluorescence in an amelanotic melanoma of the hamster,” British Journal Cancer (1994), vol. 70, pp. 826-833.
Dougherty, T.J., “Activated Dyes as Antitumor Agents”, Journal of the National Cancer Institute, 52. 1333-1336, (Apr. 1974).
Kelly, J.F. and M.E. Snell; “Hematoporphyrin Derivative: A Possible Aid in the Diagnosis and Therapy of Carcinoma of the Bladder”, The Journal of Urology, vol. 115, pp. 150-151, (Feb. 1976).
Kloek, J. and Gerard M.J. Beijersbergen van Henegouwen; “Prodrugs of 5-Aminolevulinic Acid for Photodynamic Therapy”, Photochemistry and Photobiology, 64 (6), 994-1000, (1996).
Qian, P., et al.; “A Comparison of Different Photosensitizing Dyes with respect to Uptake C3H-Tumors and Tissues of Mice”, Cancer Letters, 36, 1-10, (1987).
Ariens, E. J.; Drug Design; Academic Press; New York; pp. 8-11, 70-71. (1971).
Cotton, F. A. and G. Wilkinson; Advanced Inorganic Chemistry. 5th ed. John Wiley and Sons. New York; pp. 305-309, 382-386. (1988).
Davies, A. G.; “Detection and Analysis: Hazards and Safeguards” Organic Peroxides, Butterworth and Co. London pp. 193-200. 1961.
Morrison, R. T. et al.; “Functional Derivatives of CarboxylicAcids” Organic Chemistry 3rd Ed.; Allyn and Bacon; Boston; pp. 631, 666, 668-669, 673. (1973).
Gawell, L. et al.; “Synthesis of 5-Substituted 5-Hydroxy-2-pyrrolidones, Metabolites of the Antipsychotic Benzamide Remooxipride” Acta Chemica Scandinavica; 43; pp. 476-480. (1989).
Salerni, O.L., et al., “Synthesis of δ-Aminolaevulinic Acid Analogues as Potential Antimalarial Agents”, J. Chem. Soc. C, pp. 1399-1401, (1968).
Schulz, G. and W. Steglich; “3-Imidazoline und Δ3-Tetrahydropyrimidine durch Thermolyse von 3-Oxazolin-5-onen aus N-Acyldipeptiden” Chemische Berichte; 113 (2); pp. 770-786. (1980).
Chemical Abstract Registry Nos. 79416-27-6, 163271-25-8, 186146-43-0, 163271-24-7, 186410-01-5, 204326-60-3, 140898-97-1, 140898-99-3, 140898-98-2, 140899-00-9, 140899-01-0, 140899-02-1, 163271-28-1, 140899-03-2, 163271-21-4, 163271-26-9, 163271-27-0, 163271-20-3, 123498-44-2, 163271-23-6, 163271-22-5, 186410-02-6, 186410-03-7.
Whitaker et al., “Photosensitization of pancreatic tumour cells by δ-aminolaevulinic acid esters,” Anti-Cancer Drug Design (2000), vol. 15, pp. 161-170.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Esters of 5-aminolevulinic acid as photosensitizing agents... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Esters of 5-aminolevulinic acid as photosensitizing agents..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Esters of 5-aminolevulinic acid as photosensitizing agents... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4214368

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.