Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2006-01-31
2006-01-31
Zucker, Paul A. (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S506000, C560S155000, C560S170000, C206S569000, C206S570000
Reexamination Certificate
active
06992107
ABSTRACT:
The present invention provides a compound of formula I;in-line-formulae description="In-line Formulae" end="lead"?R22N—CH2COCH2—CH2CO—OR1 (I)in-line-formulae description="In-line Formulae" end="tail"?wherein R1represents (a) an optionally substituted branched C6-30alkyl group, comprising a straight chain C4-29alkyl group, branched by substitution with one or more C1-6alkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more —O—, NR3—, —S— or PR3— groups; R2, each of which may be the same or different, represents a hydrogen atom or a group R1, wherein R1represents (a) an optionally substituted branched C5-30alkyl group, comprising a straight chain C4-29alkyl group, branched by substitution with one or more C1-6alkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more —O—, NR3—, —S— or PR3— groups; and R3represents a hydrogen or C1-6alkyl group, and salts thereof for use in photochemotherapy or diagnosis. Pharmaceutical compositions comprising said compound, methods of diagnosis or photochemotherapy using said compound and related compounds and compositions, and products and kits comprising said compounds are also provided.
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Bjorseth Alf
Gierskcky Karl E.
Moan Johan
Peng Qian
Steen Harald
Kenyon & Kenyon
Photocure ASA
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