Esters of 3-demethylthiocolchicine and n-acyl analogs

Details Esters of 3-demethylthiocolchicine and n-acyl analogs Esters of 3-demethylthiocolchicine and n-acyl analogs

1991-04-18

1992-12-29

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560108, 558271, 564211, 564212, 564213, C07C 6900

Patent

active

051753421

ABSTRACT:
The present invention relates to esters of 3-demethylthiocolchicine and N-acyl analogs thereof having the following formula: ##STR1## wherein R is O-CO-alkyl, O-CO-CH.sub.2 Oalkyl, O-CO-Phenyl, O-COOalkyl; the alkyl group having from 1 to 4 carbon atoms and the Ac group representing acetyl and its higher homologs, benzoyl, alkoxyacetyl, or haloacetyl.
The invention further relates to processes for preparing these ester compounds, pharmaceutical compositions thereof and methods for treating diseases such as gout, Mediterranean fever and liver disorders.

REFERENCES:
patent: 2820029 (1958-01-01), Muller et al.
patent: 3997506 (1976-12-01), Dugat
De, Kalgon, K. et al., J. Carbohydr. Nucleosides, Nucleotides 2(2) 171-176 1975.
Capraso et al., pp. 48-57, "The Alkaloids" vol. XXIII 1984, Academic Press, N.Y.
Kerekes et al., J. Med. Chem. 28(9), 1204-1208, 1985.
Brossi et al., Medicinal Research Reviews 8(1), 77-94, 1988.
Kerekes et al., Helvetica Chimica Acta 68, 571-580, 1985.

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