Esters of 2-thenoylmercaptopropionylglycine with substituted hyd

Details Esters of 2-thenoylmercaptopropionylglycine with substituted hyd Esters of 2-thenoylmercaptopropionylglycine with substituted hyd

1982-06-24

1984-09-18

Siegel, Alan

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

549 71, 549 72, A61K 3138, C07D33324

Patent

active

044724241

ABSTRACT:
Esters of 2-thenoylmercaptopropionylglycine with substituted hydroxybenzenes, having general formula ##STR1## wherein R is p-acetamidophenyl, p-propyloxy carbophenyl or o-alkyloxycarbophenyl wherein the oxyalkyl radical contains 1-4 carbon atoms, are prepared by reacting 2-thenoylmercaptopropionylglycine with an alkylchloroformate thus obtaining a mixed anhydride which is reacted with the proper substituted hydroxybenzene selected among p-hydroxybenzeneacetamide, propyl p-hydroxybenzoate and alkyl o-hydroxybenzoate. These esters are useful therapeutical agents as mucolytic and antiinflammatory agents.

REFERENCES:
patent: 4363920 (1982-12-01), Viscardi
Wagner et al., Synth. Org. Chem., (1965), p. 482.

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