Esters of 2-substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes havin

Details Esters of 2-substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes havin Esters of 2-substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes havin

1977-09-02

1978-09-05

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

2603402, 560 71, 2603409R, 26034859, C07D31736

Patent

active

041121147

ABSTRACT:
Esters of 2-substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: ##STR1## where R' is --CH.sub.2 --CH.dbd.CH.sub.2, --CH.sub.2 --CH(OH)--CH.sub.2 OH, ##STR2## where Y is either O or S, or ##STR3## where R.sup.4 and R.sup.5 are independently hydrogen, alkyl having 1 to 6 carbon atoms, phenyl, or benzyl, or together R.sup.4 and R.sup.5 form an alkylene bridge having 4, 5 or 6 carbon atoms; one of R.sup.2 and R.sup.3 is hydrogen and the other is hydrogen, methyl, or ethyl, or together R.sup.2 and R.sup.3 are methylene. The compounds have anti-inflammatory, analgesic, and antipyretic activities and, accordingly, are useful in the treatment of inflammation, pain and/or pyrexia.

REFERENCES:
patent: 4020094 (1977-04-01), Nelson et al.

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