Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2005-11-01
2005-11-01
Bugaisky, Gabriele E. (Department: 1653)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S196000
Reexamination Certificate
active
06960460
ABSTRACT:
An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I:wherein R1is hydrogen or methyl, and R2is C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C1-C4haloalkyl, a C5-C9aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C5-C9fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (R)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
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Ishii Takeshi
Mitsuda Satoshi
Bugaisky Gabriele E.
Sumitomo Chemical Company Limited
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