Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1997-11-26
2000-07-11
Carlson, Karen Cochrane
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4352523, 43525233, 43525411, 435325, 4353201, 435 691, C12N 916, C12N 100, C12N 121, C12N 510, C12N 1555, C12N 1563
Patent
active
060871458
ABSTRACT:
An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: ##STR1## wherein R.sub.1 is hydrogen or methyl, and R.sub.2 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.1 -C.sub.4 haloalkyl, a C.sub.5 -C.sub.9 aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C.sub.5 -C.sub.9 fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (R)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
REFERENCES:
patent: 4607013 (1986-08-01), Mitsuda et al.
patent: 5290694 (1994-03-01), Nakanishi et al.
patent: 5306636 (1994-04-01), Iizumi et al.
Kinoshita et al. Factors infuencing enantioselectivity of lipase-catalyzed hydrolysis. Tetrahedron 52 (15): 5397-5406, Apr. 8, 1996.
Hirose et al. Inversion of enantioselectivity in hydrolysis of 1,4-dihydropyridines by point mutation of lipase PS. Tetrahedron Lett. 36(7): 1063-1066, Feb. 13, 1995.
Sih et al. Differences in reactivity and enantioselectivity in lipase reactions with carboxylic esters and alcohols bearing the same stereogenic center. Tetrahedron:Assymetry 6: 357-360, Feb. 2, 1995.
JP 03 047079 A (Kurita Water Ind Ltd), Feb. 28, 1991 *Abstract* Database WPT Week 9115 Derwent Publications LTD, London, GB.
Schrag et al., Structure, vol. 5, No. 2, pp. 187-202 (1997).
Frenken et al., Applied and Environmental Microbiology, vol. 58, No. 12, pp. 3787-3791 (Dec. 1992).
Jorgensen et al., Journal of Bacteriology, vol. 173, No. 2, 559-567 (1991).
Sugihara et al., J. Biochem. 112, 598-603 (1992).
Ishii Takeshi
Mitsuda Satoshi
Bugaisky Gabriele E.
Carlson Karen Cochrane
Sumitomo Chemical Company Limited
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