Ester-substituted diaminedithiols and radiolabeled complexes the

Details Ester-substituted diaminedithiols and radiolabeled complexes the Ester-substituted diaminedithiols and radiolabeled complexes the

1988-01-26

1994-01-18

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, 534 14, 560 9, 560147, A61K 4902, A61K 4300

Patent

active

052798119

ABSTRACT:
Radiopharmaceuticals consisting essentially of a lipophilic, charge neutral radionuclide complex of a diaminedithiol ligand having 1-4 ester groups of the formula --A--COOR where A is a straight or branched chain alkylene of 0-10 carbon atoms and R is an alkyl group of 1-10 carbon atoms are useful in radioimaging brain perfusion in primates. Ester-substituted diaminedithiols in sterile, pharmaceutically acceptable form, and kits of the diaminedithiols and sterile, non-pyrogenic reducing agents for reducing preselected radionuclides are also provided. Technetium-99m is a preferred radionuclide.

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