Ester-substituted diaminedithiols and radiolabeled complexes the

Details Ester-substituted diaminedithiols and radiolabeled complexes the Ester-substituted diaminedithiols and radiolabeled complexes the

1993-10-20

1995-07-11

Wu, Sean M.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds bacterium or component thereof or substance produced...

560 9, 560 18, 534 14, A61K 5104, C07C32100, C07F 1300

Patent

active

054319005

ABSTRACT:
Radiopharmaceuticals consisting essentially of a lipophilic, charge neutral radionuclide complex of a diaminedithiol ligand having 1-4 ester groups of the formula --A--COOR where A is a straight or branched chain alkylene of 0-10 carbon atoms and R is an alkyl group of 1-10 carbon atoms are useful in radioimaging brain perfusion in primates. Ester-substituted diaminedithiols in sterile, pharmaceutically acceptable form, and kits of the diaminedithiols and sterile, non-pyrogenic reducing agents for reducing preselected radionuclides are also provided. Technetium-99m is a preferred radionuclide.

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