Ester of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid having an

Details Ester of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid having an Ester of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid having an

1983-03-04

1985-06-04

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548539, C07D207323, A61K 3140

Patent

active

045215383

ABSTRACT:
1-methyl-5-p-toluoylpyrrole-2-acetic acid guaiacyl ester, which possesses antiinflammatory, antipyretic, mucolytic and antitussive properties, is disclosed.
This ester is prepared by reacting guaiacol with an activated derivative of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid of formula ##STR1## wherein X is an activating group suitable for promoting the formation of an ester bond.

REFERENCES:
patent: 3752826 (1973-08-01), Carson
patent: 4284785 (1981-08-01), Hanifin, Jr. et al.
patent: 4379793 (1983-04-01), Calzada Badia et al.
patent: 4396626 (1983-08-01), Ward et al.
Baiocchi et al., Chem. Abstracts, vol. 90:54686e (1979).
Rojo et al., Chem. Abstracts, vol. 91:13488u (1979).
Carenini et al., Chem. Abstracts, vol. 91 (1979), p. 469, Abstract #4999j.

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