Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1982-07-16
1983-11-22
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
2602452R, 2602391, 542420, C07D49900, A61K 31425
Patent
active
044168918
ABSTRACT:
(5-Methyl-2-oxo-1,3-dioxolen-4-yl)methyl 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanate of the following formula (I) ##STR1## or its pharmaceutically acceptable acid addition salt. The compound is useful as an antibacterial agent and may be prepared by reacting (5-methyl-2-oxo-1,3-dioxolen-4-yl)-methyl 6-aminopenicillanate of the following formula (II) ##STR2## or its acid addition salt with chloro-N,N-hexamethyleneformiminium chloride, and as required, converting the resulting compound to its pharmaceutically acceptable acid addition salt.
REFERENCES:
patent: 3755588 (1973-08-01), Lund
patent: 3957764 (1976-05-01), Lund
patent: 4089963 (1978-05-01), Bamberg et al.
Nature New Biology, vol. 236, pp. 135-137, 4-5-72.
Chemotherapy 21:146-166 (1975).
Code of Federal Regulations, 21, Food & Drugs, Parts 100 to 199, pp. 697-698, 4-1-78.
Ikeda Shoji
Sakamoto Fumio
Tsukamoto Goro
Kanebo Ltd.
Rizzo Nicholas S.
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