Ester of 1,1-dioxopenicillanic acid, and use thereof as .beta.-l

Details Ester of 1,1-dioxopenicillanic acid, and use thereof as .beta.-l Ester of 1,1-dioxopenicillanic acid, and use thereof as .beta.-l

1982-07-08

1984-05-15

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

424270, 2602452R, C07D49900, A61K 31425

Patent

active

044487690

ABSTRACT:
A 1,1-dioxopenicillanic acid ester represented by formula (I) ##STR1## wherein R represents a methyl or phenyl group. The ester of formula (I) may be prepared by reacting 1,1-dioxopenicillanic acid or its salt with a compound represented by formula (III) ##STR2## wherein R is as defined above, and X represents a halogen atom, or by oxidizing a compound of formula (V) ##STR3## wherein R is as defined above. The ester of the formula (I) is useful as a .beta.-lactamase inhibitor and may be used in association with a .beta.-lactam antibiotic.

REFERENCES:
patent: 4241050 (1980-12-01), Barth
Antimicrobial Agents and Chemotherapy, 1978, pp. 414-419, American Society for Microbiology.
Current Chemotherapy and Infectious Disease, 1980, p. 353, American Society for Microbiology.

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