Ester derivatives of deoxyfluorouridine

Details Ester derivatives of deoxyfluorouridine Ester derivatives of deoxyfluorouridine

1981-08-06

1983-11-22

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 23, A61K 3170, C07H 1908

Patent

active

044168756

ABSTRACT:
New ester derivatives of deoxyfluorouridine of the general formula: ##STR1## wherein R and R.sup.40, may be identical or different, and may be hydrogen, halogen or methyl and n is 3 or 4. These derivatives are prepared by acylating a 2'-deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine with corresponding benzoyl halides and are useful as active ingredients for anti-tumor agents, especially for oral administeration.

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