Ester derivatives of ascorbic and 2-keto acid saccharides

Details Ester derivatives of ascorbic and 2-keto acid saccharides Ester derivatives of ascorbic and 2-keto acid saccharides

2011-01-18

2011-01-18

Olson, Eric S (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S063000, C514S530000, C514S548000, C514S551000, C514S552000, C514S546000, C536S055000, C536S055300, C536S119000, C556S437000, C556S430000, C556S457000, C556S489000, C556S482000

Reexamination Certificate

active

07871987

ABSTRACT:
Novel ester derivatives of ascorbic acid and 2-keto-acid saccharides are provided wherein the ester is introduced by ester bond formation between at least one hydroxy-functionality on the ascorbic acid or 2-keto-acid saccharide and a carboxy-functional organosiloxane, or between a 2-keto-gulonic acid and a hydroxy-functional organosiloxane, as well as methods for their synthesis. Treatment, cosmetic, and personal care formulations comprising the novel esters are also provided, including controlled release forms thereof.

REFERENCES:
Wagner et al., “Silicon-Modified Carbohydrate Surfactants III: Cationic and Anionic Compounds” Applied Organometallic Chemistry (1997) vol. 11, pp. 523-538.
Akimoto et al., “Preparation of oligodimethylsiloxanes with sugar moiety at a terminal group as a transdermal penetration enhancer” Macromolecular Chemistry and Physics (2000) vol. 201, pp. 2729-2734.

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