Ester derivatives of alkoxybenzoyldeoxyfluorouridine

Details Ester derivatives of alkoxybenzoyldeoxyfluorouridine Ester derivatives of alkoxybenzoyldeoxyfluorouridine

1981-08-10

1984-01-10

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 23, A61K 3170, C07H 1908

Patent

active

044253354

ABSTRACT:
New ester derivatives of alkoxybenzoyldeoxyfluorouridine of the general formula ##STR1## wherein R stands for an alkoxy group having 1 to 4 carbon atoms, m for 1 or 2, and n for 3 or 4 with the proviso that when m is 2, the adjacent two R's may be combined to form an alkylenedioxy group as a whole. These derivatives are prepared by acylating a 2'-deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine with corresponding benzoyl halides and are useful as active ingredients for anti-tumor agents, especially for oral administration.

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