Ester cleavage process for use with .beta.-lactams

Details Ester cleavage process for use with .beta.-lactams Ester cleavage process for use with .beta.-lactams

1992-02-18

1994-04-12

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540205, 540222, 540225, 540227, 540310, C07D49908, C07D50104

Patent

active

053027116

ABSTRACT:
The present invention provides a novel ester cleavage process for use with .beta.-lactams. The process is useful because of mild conditions necessary to complete the reaction, such conditions being especially suitable for .beta.-lactams.

REFERENCES:
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patent: 5095107 (1992-03-01), Blanchard
patent: 5246926 (1993-09-01), Bateson et al.
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McMurry, J. E. and Wong, G. B., "An improved method for the cleavage of methyl esters," Synthetic Communications, 2(6), 389-394 (1972).
Mochida, K. and Hirata, T., "Synthetic Studies on 1-Carbacephem Antibiotics: New Synthetic approach to 3H-Carbacephems," Chem. Pharm. Bull., 36(9), 3642-3645, (1988).
Martinez, A. G., Barcina, J. O., del Veccio, H., Hanack, M. and Subramanian, L. R., "Non-hydrolytic Cleavage of Esters with Magnesium Iodide in Aprotic Non-polar Solvents," Tetrahedron Letters, 32 (42) 5931-5934 (1991).
Olsher, U., Izatt, R. M., Bradshaw, J. S., Dalley, N. K., "Coordination Chemistry of Lithium Ion: A Crystal and Molecular Structure Review," Chem. Rev., 91, 137-164, (1991).

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