Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1991-11-27
1992-07-21
Nucker, Christine
Chemistry: molecular biology and microbiology
Spore forming or isolating process
43524021, C12N 506, C12N 508
Patent
active
051322226
ABSTRACT:
A novel established cell line, KML.sub.1-7, obtained by collecting lymphoid cells from an animal with autoimmune disease, culturing them in a culture medium containing the supernatant of a culture in which lymphoid cells of animal origin have been grown in the presence of a mitogen, and continuing the culture for a period of 8 months until the cells are able to grow in the absence of the aforesaid supernatant. This established cell line has the following properties.
REFERENCES:
Kanai, Y. et al. (II) "Establishment and Functions of an MRL/Mp-lpr/lpr Lymphoma Line with Null Cell Properties: Its Roles for Anti-DNA Antibody Production in vitro," In Kano et al. (ed.) Cellular, Molecular and Genetic Approaches to Immunodiagnosis and Immunotherapy; VIIIth International Conference on Labeled Antibodies, Tokyo, Japan, Nov. 5-7, 1985, Karger, Basel, 1987, pp. 283-288.
Immunophysiology, "Interleukins and Interferons Acting on B Lymphocytes", R. L. Coffman, et al. Oxford Univ. Press, 1990.
Kanai, Y. et al. "An Established MRL/Mp-lpr/lpr Cell Line with Null Cell Properties Produces a B Cell Differentiation Factor(s) That Promotes Anti-Single-Stranded DNA Antibody Production in MRL Spleen Cell Culture," Int. Archs. Allergy Appl. Immun. 81: 92-94, Sep. 1986.
Rosenberg, Y. J. et al. "T Cells from Autoimmune `IL-2-Defective` MRL-lpr/lpr Mice Continue to Grow In vitro and Produce IL2 Constitutively," J. Immunol. 133(5): 2545-2548, Nov., 1984.
Lewis, D. E. et al. "Flow cytometry analysis of T cells and continuous T-cell lines from autoimmune MRL/l mice" Nature 289: 298-300, Jan. 22, 1981.
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Prud'Homme, G. J. et al. "Identification of a B Cell Differentiation Factor(s) Produced by proliferating T Cells in Murine Lupus Strains of the lpr/lpr Genotype," J. Exp. Med. 157:730-742, Feb. 1983.
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Awaya Akira
Kanai Yoshiyuki
Cunningham T. M.
Mitsui Toatsu Chemicals Incorporated
Nucker Christine
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