Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1992-05-05
1993-10-05
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 851, 424 857, 530829, 530868, 530350, C07K 1300, C07K 1500, C07K 1506, A61K 3702
Patent
active
052506614
ABSTRACT:
B cell differentiation factor which acts on B cells and participates in their differentiation into antibody-producing cells is produced by an established cell line.
REFERENCES:
patent: 5132222 (1992-07-01), Kanagi et al.
A. Muraguchi, et al. J. Immunol, vol. 127, pp. 412-416. Aug. 1981.
T. Teranashi, et al. J. Immunol, vol. 128(4), pp. 1903-1908.
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Kanai, Y., et al., Int. Archs Allergy Appl. Immunol. 81: 92-4 (1986), "An established MRL/MP-lpr/lpr cell line with Nyll Cell properties produces a B cell differentiation factor(s) . . . ".
Kamai, Y., et al. Mol. Biol. Rep. 15(3-4):133 (1991) "Molecular Cloning of Nucleobindin, a novel 55 KD DNA-Binding Protein that Induces protection of lgG anti-DNA antibodies . . . ".
Kamai, Y. et al., Immuno Lett 32:43-48 (1992), "Purification of a novel B cell growth and differentiation factor associated with lupus syndrome".
Miura, K. et al., Biochem. Biophys Res. Comm. 187:375-80 (1992), "Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine-zipper Structure".
Kanai, Y. et al (II) "Establishment and Function of an MRL/MP-1pr1pr Lymphoma line with Null Cell Properties: Its Roles for Anti-DNA Antibody Production in vitro," In Kano et al (ed) Cellular, Molecular and Genetic Approaches to Immunodiagnosis and Immunotherapy; VIIIth Internatonal Conference on Labeled Antibodies, Tokyo, Japan, No. 5-7, 1985, Karger, Basel, 1987, pp. 283-288.
Immunophysiology "Interleukins and Interferons Acting on B Lymphocytes". R. L. Coffman et al. Oxford Univ. Press. 1990.
The Cytokine Handbook, Academic Press 1991 Chapter 9 Sanderson "Interleukin-7" pp. 149-190.
J. Immunol. vol. 134, No. 6, Jun. 1985, 3944-51 Harada et al "BCGFII Activity on Activated B Cells of a Purified etc".
Abstract JP 60-169424 Derwent.
Awaya Akira
Kanai Yoshiyuki
Cunningham T.
Mitsui Toatsu Chemicals Incorporated
Nucker Christine M.
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