Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Endocrine system – other than the thymus gland
Patent
1991-05-23
1993-05-04
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Endocrine system, other than the thymus gland
514 2, 514 21, 530324, 435 712, A61K 3724
Patent
active
052080412
ABSTRACT:
Human parathyroid hormone is provided in an ultrapure form characterized by the absence of protein contaminants detectable by capillary electrophoresis analysis. A method for obtaining such ultrapure human parathyroid hormone is also described.
REFERENCES:
patent: 3886132 (1975-05-01), Brewer et al.
Rabbani et al. CA 109:5186 (1988).
Fairwell et al. CA 98: 198739 (1983).
Sung, et al, "Specific Degenerate Codons Enhanced Selective Expression Of Human Parathyroid Hormone in Escherichia Coli", The Journal of Biological Chemistry, vol. 266, pp. 2831-2835, (1991).
Rabbani, et al, "Recombinant Human Parathyroid Hormone Synthesized in Escherichia Coli", The Journal Of Biological Chemistry, vol. 263, pp. 1307-1313, (1988).
Hogset, et al, "Expression and Characterization Of A Recombinant Human Parathyroid Hormone Secreted By Escherichia Coli Employing the Staphylococcal Protein A Promoter And Signal Sequence", The Journal Of Biological Chemistry.
Kimura, et al, "Solution Synthesis Of [ASN.sup.76 ]-Human Parathyroid Hormone (1-84)", Biochemical And Biophysical Research Communications, vol. 114, pp. 493-499, (1983).
Allelix Biopharmaceuticals Inc.
Glaxo Canada Inc.
Robinson Douglas W.
Witz Jean C.
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