Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-08-07
2007-08-07
Carlson, Karen Cochrane (Department: 1653)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007800, C435S007920, C435S007930, C435S007940, C435S007950
Reexamination Certificate
active
10322579
ABSTRACT:
The present invention relates to a new essential downstream component of the Wnt/Wingless (Wnt/Wg) signaling pathway and therapeutic and diagnostic applications based thereon. The invention relates to nucleotide sequences of theDrosophila melanogasterlegless (lgs) gene, of its encoded proteins, as well as derivatives (e.g., fragments) and analogues thereof. The invention further includes vertebrate and invertebrate homologues of the Lgs protein, comprising proteins that contain a contiguous stretch of amino acids with similarity to theDrosophilalgs gene. The invention further relates to the function of theDrosophilaand the human Lgs proteins. Methods for producing the Lgs proteins, derivatives and analogs, e.g., by recombinant means and antibodies to Lgs are provided by the present invention. In addition, the invention also relates to the therapeutic and diagnostic methods and compositions based on Lgs proteins and nucleic acids or fragments thereof.
REFERENCES:
patent: 2004/0073001 (2004-04-01), Akiyama et al.
patent: WO 02/24738 (2002-03-01), None
Basler Konrad
Brunner Erich
Froesch Barbara
Kramps Thomas
Peter Oliver
Carlson Karen Cochrane
Sughrue & Mion, PLLC
Universität Zurich
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