Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Reexamination Certificate
2005-10-11
2009-12-08
Martinell, James (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
C435S007100
Reexamination Certificate
active
07629141
ABSTRACT:
The invention includes a database of candidate essential genes inPseudomonas aeruginosa, as well as other important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacterial agents suitable for treating and preventingPseudomonas aeruginosainfections. The invention includes methods for confirming the essentiality or importance of candidate genes, as well as methods for utilizing those genes to screen for new antibacterial drugs. The invention also includes the antibacterial agents identified using the disclosed methods, as well as methods of using the same for treating and preventingPseudomonasinfection.
REFERENCES:
patent: 5706498 (1998-01-01), Fujiyama et al.
patent: 5876931 (1999-03-01), Holden
patent: 6037137 (2000-03-01), Komoriya et al.
Onishi et al, Science 274: 980 (1996).
Costerton et al., “Bacterial Biofilms: A common cause of persistant infections,”Science 284, 1318-22, May 21, 1999.
Hyland et al., “Cloning, expression, and purification of UDP-3-O-acyl-G1cNAc deacetylase fromPseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway,”J. Bacteriol. 179, 2029-37, 1997.
Stover et al., “Complete genome sequence ofPseudomonas aeruginosaPA01, an opportunistic pathogen,”Nature 406, 959-64, Aug. 31, 2000.
Bruce Kim Folger
Hou Kevin
Warrener Paul
Gorman Robert J.
Hemmendinger Lisa M.
Lee Helen
Martinell James
Novartis Vaccines and Diagnostics Inc.
LandOfFree
Essential and important genes of Pseudomonas aeruginosa... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Essential and important genes of Pseudomonas aeruginosa..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Essential and important genes of Pseudomonas aeruginosa... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4149428